A Case of SF3B1-Positive Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis
نویسندگان
چکیده
منابع مشابه
Refractory anemia with ring sideroblasts and thrombocytosis
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 58-year-old man presented with a 1-year history of transfusion-dependent anemia. On examination, he had pallor and his spleen was barely palpable. 9 /L. A blood differential count showed 40% neutrophils, 54% lymphocytes, 2% monocytes, and 3% eosinophils. A...
متن کاملSomatic SF3B1 mutation in myelodysplasia with ring sideroblasts.
BACKGROUND Myelodysplastic syndromes are a diverse and common group of chronic hematologic cancers. The identification of new genetic lesions could facilitate new diagnostic and therapeutic strategies. METHODS We used massively parallel sequencing technology to identify somatically acquired point mutations across all protein-coding exons in the genome in 9 patients with low-grade myelodysplas...
متن کاملA case of refractory anemia with ring sideroblasts and associated thrombocytosis.
A 69-year-old man presented with a 2-year history of progressive thrombocytosis, referred to exclude essential thrombocythemia. He had been asymptomatic apart from intermittent dysphagia and a brief episode of amaurosis fugax a few weeks prior to his presentation. On examination, he had no palpable splenomegaly. Complete blood count showed the following: hemoglobin, 129 g/L; mean corpuscular vo...
متن کاملRefractory anemia with ring sideroblasts associated with thrombocytosis (RARS-T).
A 75-year-old woman who was previously healthy was investigated for chronic anemia. Her hemoglobin was 94 g/L with a mean corpuscular volume of 108 fL, white cell counts were normal, and platelet count was high (480 3 10/L). Blood film showed marked red cell anisocytosis with dimorphic pattern, stomatocytes, no neutrophil dysplasia, and no blasts (panel A-B). Bone marrow aspirate smear demonstr...
متن کاملRefractory anemia with ring sideroblasts associated with marked thrombocytosis: case report and literature review.
"Refractory anemia with ring sideroblasts and thrombocytosis" (RARS-T) is a rare disease, a provisional entity, with a controversial status in the 2008 revised WHO classification. Even at present time, RARS-T is a matter of debate whether it is a distinct clinicopathological entity or more likely a constellation of clinical and pathological features of two well-defined myeloid neoplasms, myelod...
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ژورنال
عنوان ژورنال: Turkish Journal of Hematology
سال: 2019
ISSN: 1300-7777
DOI: 10.4274/tjh.galenos.2018.2018.0267